Set Roberts, a major specialist in the development and introduction of new drugs, a pharmacologist who has more than 10 years of research in the field of steroid use, spoke about the effect of steroids on the human body in a number of his works.
The effect of trembolone
So, the derivative of nandrolone - trenbolone, does not have a methyl group, being in position 19. It has a great ability to strongly bind not only to progesterone receptors, but also to androgenic ones. Most likely, such strong bonds influence the fact that trenbolone acts as an antagonist in relation to the progesterone receptor. As a rule, it is generally accepted that gynecomastia is caused by progesterone antagonists. Indeed, studies confirm that trenbolone is the cause of a decrease in estrogen receptor levels in the body. In addition, this same strong connection is directly the reason that the person taking this drug may feel a decrease in his libido, and in some cases even lose it. And this applies to almost all adherents of the drug.
Freely marketed, this androgen is not metabolized in skeletal muscle to the level of 3-alpha metabolites. As a result, a quick and noticeable increase in size and level of strength is felt.
Tests carried out on live animals yielded results suggesting that trenbolone is the cause of the appearance of antiglucocorticoid effects. However, there is no evidence that this drug can have the exact same effect on the human body. Trenbolone cannot be converted to estrogen. Despite the prevailing opinion that it is impossible to reduce trenbolone by 5-alpha, some scientists in their scientific studies prove that this steroid is much less active in those tissues in which a large amount of 5-alpha reductase is contained.
Exactly the same effect occurs with nandrolone. And, given that trenbolone is also a 19-norsteroid, there is every reason to say that it, in fact, is reduced to weaker metabolites. This also explains the occurrence of gynecomastia, cases when the body stopped producing testosterone, despite the fact that estrogen cannot be converted from trenbolone. Androgen-estrogen balance is disturbed as a result of a decrease in androgen stimulation due to the production of not so powerful 5-alpha-reduced androgens. All this is the reason for the increased content of estrogenic signals in the hypothalamus.
The main problem with the use of trenbolone can be considered that it is almost impossible to get this drug, made directly for human consumption. Such a drug is called parabolan, but it is almost completely inaccessible to consumption. In addition, the black market is currently trading trenbolan in its entirety, which is intended for use by cattle. This drug is called Finaplex, and in clandestine laboratories, this steroid is converted into an injectable liquid. This is done by dissolving the ipplentant pellets in the solvent, and then the resulting mixture is boiled. As a result, the drug can be injected into the body. In addition, it is not a big problem to independently get all the necessary equipment for its production and without much effort to get trenbolone from pellets at home. However, one must always remember the sterility problem of such an underground production. The risk of infections, sepsis, abscess increases. Even the possibility of anaphylactic shock is not excluded, and this is a direct threat of death. In addition, it must be remembered that those pellet solvents that are used to obtain the injection mixture are not intended for these purposes at all, therefore, the risk of poisoning increases accordingly.
Now trenbolone is available for consumption in the form of enanthate, acetate or hexahydrobenzylcarbonate ester. The latter is taken either every day, or with one-day breaks. Previously, it was a product for use in veterinary medicine and it was called Finajekt. However, this drug is not currently available. But in clandestine laboratories, enanthate is produced, which can be consumed no more than once a week. But even in this case, his active supporters, as a rule, take this drug much more often. The age of hexahydrobenzyl carbonate ether was not very long. Originally released under the name Parabolan and designed specifically for human use, it lasted a very short time on the market. This was a kind of signal for clandestine manufacturers who constantly produce similar analogues of the enanthate ester. Such drugs have an even shorter century, are also administered by injection, once a week or ten days, and sometimes every two weeks. Together with other steroids, trenbolone, which is a fairly powerful anabolic, can significantly increase both weight and strength. But, in addition to pronounced anabolic properties, trenbolone also has such side effects as the appearance of acne, hair loss, increased blood pressure, and especially this drug negatively affects the functioning of the kidneys and the genitourinary system. In fairness, it is worth recognizing that this effect does not have its confirmation in the scientific literature by conducting relevant scientific experiments, but it is known that androgen stimulation affects the functioning of the kidneys. Trenbolone, causing hypertension, is thus quite harmful to the kidneys. Therefore, taking this steroid should be done with extreme caution.
The effect of Primobolan
Under the name Primobolan, a synthetic derivative of dihydrotestosterone, methenolone, is on the market. This is a type of acetate ester that must be taken orally. However, previously there were versions of this drug that allowed injections. According to many, Primobolan is a completely ineffective drug, so little attention is paid to this steroid. In addition, its high cost discourages. Another disadvantage for many is the fact that this method of taking the drug is not effective due to non-alkylation of 17-alpha methenolone. It seems that the 1-methyl group is able to protect it from the effects of metabolism to 1- or 2-hydroxymetabolite to a certain level. But even if this is true, the acetate does not show sufficient oral biological activity, therefore, in order to achieve a good effect, it is necessary to take fairly large doses of the drug.
This steroid does not aromatize due to the fact that it is a derivative of dihydrotestosterone. In addition, it is not too progestationally active. Thus, primobolan most likely exhibits the properties inherent to an aromatase inhibitor due to the fact that it is, in fact, a derivative of dihydrotestosterone. This property has secured the reputation of Primobolan as a steroid “dry gainer”, which has a completely insignificant inhibitory property. Given that methenolone is initially reduced by 5-alpha, then this enzyme does not metabolize it later. However, it is worth remembering that this steroid can be metabolized directly in skeletal muscle under the influence of 3-alpha hydroxysteroid dehydrogenase. But such metabolism occurs significantly less strongly than DHT. As a result of such effects, a weaker ratio of androgenic and anabolic activities can be observed in its weaker molecule. Also, methenolone does not bind too much with a substance such as globulin, which binds sex hormone. Also, there is no convincing evidence that methenolone enters at least a slight interaction with progesterone receptors or a glucocorticoid. So, primobolan is not very conducive to weight gain, however, this effect is explained by the fact that fat and water in the body do not stay for a long time. The difference between primobolan is that it is used when they are trying to gain quality mass, but at the same time get a small amount of negative side effects, or not get them at all. But at the same time, it will be much more preferable to use this drug by injection. If women use this drug in small amounts, it is even possible to avoid the most minor side effects. According to some researchers, taking primobolan in limited quantities does not even affect the cessation of the production of natural testosterone by the body. And its insignificant effect on the decrease in the produced testosterone is due to the fact that it does not pass into estrogen. But, nevertheless, such suppression may well increase with an increase in the amount of the drug taken. Few people know that methenolone, like oxymetholone, contributes to an increase in the number of red blood cells in the body. However, methenolone in any form, even in tablets, even in injections, has never been such a common and affordable drug as the rest of the “reserve”. Moreover, what appears on the market costs substantial amounts and is not accessible to everyone. Methenolone is a product that produces only a limited number of manufacturers and it is a deficit not only in free sale, but also in the black market.
Methenolone enanthate is an injectable form of this drug, which is known in the market as Primobolan Depot. The enanthate ether has the ability to slowly absorb by the tissues, which allows it to be introduced into the body no more than once every two weeks. But many increase the frequency of its intake by two to four times, using a steroid a couple of times a week. If you use methenolone by injection, the effect will be much stronger compared to the oral form of the use of this drug. This is because the injections are not subject to the property of first-pass metabolism. And it is constantly necessary to fight with him. If evaporation is carried out, then the ether will turn into a substance, which is the basis for methenolone.
In the form of injections, the enanthate ester, together with methenolone, is a fairly strong steroid. The dosage of this drug is up to 100 ml. per week for women and up to 600 ml. - for men. To avoid the appearance of the androgenic effect, women should not use the drug more often than once every 10 days, and best of all - even less often. In general, methenolone is by far one of the safest steroids on the market. Despite the fact that methenolone does not alkylate at C-17, the 1-methyl group is capable of causing increased liver enzymes, even if the drug is administered by injection. However, this effect is much less than when taking methandrostenolone and other C-17-acryl derivatives. Of course, this steroid does not belong to the category of drugs that allow you to get a fulminant effect. This is due to the fact that it retains water and does not have the same power as similar drugs that are injected into the body, for example, the same testosterone or nandrolone. But methenolone has its fans and followers, because, despite the lack of quick returns, it does not have significant side effects caused by taking other steroids.
Influence of Stanozolol
Stanozolol is a highly modified version of dihydrotestosterone, a synthetic one. Initially, this drug was launched on the market under the name Winstrol. In it, an additional ring system was added to the traditional and familiar structure of steroids with the presence of an A-ring. Stanozolone has rather weak binding abilities, since it does not bind well enough to the androgen receptor. But the half-life period, which lasts nine hours, can be considered quite long, as for this steroid. And this is also one of the factors that caused its low binding ability. This steroid cannot be converted into a metabolite of estrogen by the aromatization procedure, in addition, it is already reduced to 5 alpha. Therefore, further reduction is not possible. But at the same time, he has a small ability for antiaromatase. Also, Stanozolol binds very badly to SHPG, a globulin that binds sex hormone. Because of this, he is in the vast majority of cases in a free state. Although Stanozolol does not interact directly with glucocorticoid receptors, it can enter into a reaction of interaction with the STBP protein, which binds glucocorticoid. As a result, bound cortisol is ejected and begins to circulate freely. At the same time, there is scientifically confirmed evidence that stanozolol exerts an effect and releases cortisol from the adrenal glands. As a result, its level decreases, especially if you take this drug on an ongoing basis. If you stop taking the steroid, you can get the effect of "rebound", as a result of which the production of cortisol by the body increases dramatically. In addition, taking the drug can cause severe pain in all joints.
Despite the fact that stanozolol exhibits a rather large ratio of androgenic and anabolic activities, it, apparently, still refers to androgens. And its antiglucocorticoid properties increase the index of anabolism due to the binding of androgen receptors. Another effect of Stanozolol is its ability to reduce the presence of thyroxin-binding globulin in the body. But, at the same time, not as much as it happens while taking other steroids of the anabolic-androgenic group.
Stanozolol can be taken both in tablets and injected. Due to the lack of etherification properties, this steroid should be taken every day. Some manufacturers produce injectable stanozolol with fairly large crystals, so a large diameter needle is often necessary for a smooth injection procedure. Also, stanozolol is considered insufficiently effective, despite the good ratio of anabolic activity to androgenic. But this is because it does not have the ability to accumulate water in the body.